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| Catalog Code: | NB100-63079 |
| Product Name: | IL-2 Antibody |
| Product Description: | Rat Monoclonal anti-IL-2 (JES6-5H4) |
| Clone: | JES6-5H4 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Concentration: | 1 mg/ml |
| Immunogen: | Recombinant Mouse IL-2 |
| Specificity: | NB100-63079 is specific for mouse Interleukin-2 (IL-2). Murine IL-2 is a potent lymphoid cell growth factor which primarily acts on T lymphocytes. |
| Cross Reactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.5 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for ELISA, immunoprecipitation, flow cytometry / FACS analysis |
| Localization: | Secreted |
| Background: | Human interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL-2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2b |
| Host Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4 |
| Application Summary: | ELISA, immunoprecipitation, flow cytometry / FACS analysis |
| Species Summary: | Mu |
| Alternate Names: | Anti-Aldesleukin antibody, Anti-IL 2 antibody, Anti-Interleukin 2 antibody, Anti-Interleukin2 antibody, Anti-Lymphokine antibody, Anti-T Cell Growth Factor antibody, Anti-TCGF antibody |
| Package Size: | 0.5 mg |
| General References: | 1. Tachibana M. et al. (2000) Coreceptor function of mutant human CD4 molecules without affinity to gp120 of Human Imunodeficiency Virus. J. Biol. Chem. 275:20288-20294. 2. Abrams J. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples, Immunol. Rev. 127:5-24. |
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