| CatalogCode: | NB100-63049 |
| ProductName: | Ki67 Antibody |
| Product Description: | Human Monoclonal anti-Ki67 (2531) |
| Clone: | 2531 |
| Clonality: | Monoclonal |
| Immunogen: | Peptide derived from the human Ki-67 protein. Sequence GFKELFQTPG, coupled via a C-terminal cysteine to carrier proteins. |
| Specificity: | Recognises the Ki67 cell-cycle assocaited protein. Ki-67 is expressed in proliferating cells but not in quiescent cells. Expression of this antigen occurs preferentially during late G1, S, G2, and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected. Consequently, Ki-67 antigen expression is used in tumor pathology to detect proliferating cells in neoplastic diseases. In cultured cells, Ki-67 is expressed in the nucleolus of interphase cells. The Ki-67 gene contains 15 exons. The Ki-67 repeat region, within which there is a 22-amino acid Ki-67 motif, is encoded by exon 13. The shorter isoform lacks exon 7. Northern blot analysis reveals multiple transcripts ranging from approximately 8.9 to 12.5 kb in proliferating but not quiescent cells. Immunoblot analysis shows expression of 320- and 359-kD proteins. Antisense oligonucleotides inhibit cellular proliferation in a dose-dependent manner, suggesting that Ki-67 protein expression may be an absolute requirement for cell proliferation.Within cells Ki67 is predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Human ascites. |
| Uses: | This antibody is useful for ELISA, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot |
| Localization: | Nuclear |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | HuCAL Fab bivalent |
| Host_Name: | Human |
| ListPrice: | 295 |
| AppSummary: | ELISA, IHC-Fr, IHC-P, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Antigen identified by monoclonal antibody; Anti- Ki 67 antibody; Anti-Antigen KI67 antibody; Anti-KIA antibody; Anti-MKI67 antibody; Anti-Proliferation related Ki 67 antigen antibody |
| ProteinTarget: | Ki67 |
| PackageSize: | 0.1 mg |
order or
more information: | company product webpage |
| request information: |
|
|