| CatalogCode: | NB100-63011 |
| ProductName: | IL-2 Antibody |
| Product Description: | Rat Monoclonal anti-IL-2 (MQ1-17H12) |
| Clone: | MQ1-17H12 |
| Clonality: | Monoclonal |
| Specificity: | Recognises human interleukin-2 (IL-2) and may be used to detect intracellular IL-2 in flow cytometric techniques. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.5 mg Rat ascites. |
| Uses: | This antibody is useful for ELISA, flow cytometry / FACS analysis |
| Localization: | Secreted |
| Background: | Human interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL-2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG2a |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 325 |
| AppSummary: | ELISA, FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Aldesleukin antibody; Anti-IL 2 antibody; Anti-Interleukin 2 antibody; Anti-Interleukin2 antibody; Anti-Lymphokine antibody; Anti-T Cell Growth Factor antibody; Anti-TCGF antibody |
| ProteinTarget: | IL-2 |
| PackageSize: | 0.5 mg |
| GeneralRef: | 1. Yoshino, N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp. Anim. 49: 97 - 110. 2. Kim, C. et al. (2002) Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24+ V beta 11+ NKT cell subsets with distinct cytokine - producing capacity. Blood. 100: 11 - 16. |
order or
more information: | company product webpage |
| request information: |
|