| CatalogCode: | NB100-62967 |
| ProductName: | TROPONIN I Antibody |
| Product Description: | Goat Polyclonal anti-TROPONIN I |
| Clonality: | Polyclonal |
| Immunogen: | Native human cardiac troponin I, purity greater than 98%. |
| Specificity: | Recognises human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.2 mg Goat antisera. |
| Uses: | This antibody is useful for ELISA |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | PBS buffer, pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | ELISA |
| SpeciesSummary: | Hu |
| ProteinTarget: | TROPONIN I |
| PackageSize: | 0.2 mg |
| GeneralRef: | 1. Takeda, S. (2005) Crystal structure of troponin and the molecular mechanism of muscle regulation. J. Electron Microscopy 54 (supplement 1): i35-i41. 2. Jeremias, A. and Gibson, C.M. (2005) Narrative review: Alternative causes for elevated cardiac troponin levels when acute coronary syndromes are excluded. Ann. Intern Med. 142: 786-791. |
order or
more information: | company product webpage |
| request information: |
|