| CatalogCode: | NB100-62963 |
| ProductName: | TRANSFERRIN Antibody |
| Product Description: | Sheep Polyclonal anti-TRANSFERRIN |
| Clonality: | Polyclonal |
| Immunogen: | Native |
| Specificity: | Recognises human transferrin, an approximately 80kDa blood plasma glycoprotein synthesised by the liver, which contains two specific high affinity iron (Fe3+) binding sites and is responsible for the transport and supply of an exchangeable pool of iron, through binding to cell surface transferrin receptors. Transferrin is the primary blood iron transport protein and under normal conditions, approximately one-third of total blood transferrin contains bound iron. Measurement of blood transferrin levels can be used as an indicator for blood iron-carrying capacity and abnormalities of iron metabolism such as anaemia, iron overload and haemochromatosis. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 1 ml Sheep antisera. |
| Uses: | This antibody is useful for ELISA |
| Localization: | Secreted |
| Background: | Transferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins. It has a molecular weight of 77 kDa and a serum concentration range of 1800 to 2700 mg/L. It is synthesised in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. The iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/transferrin is essential in haemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Sheep |
| Buffer: | PBS buffer, pH 7.2 |
| ListPrice: | 285 |
| AppSummary: | ELISA |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Beta 1 metal binding globulin antibody; Anti-PRO1400 antibody; Anti-PRO1557 antibody; Anti-PRO2086 antibody; Anti-Serotransferrin precursor antibody; Anti-Siderophilin antibody; Anti-TF antibody; Anti-Transferin antibody |
| ProteinTarget: | TRANSFERRIN |
| PackageSize: | 1 ml |
| GeneralRef: | 1. Rouault, T.A. (2003) How mammals acquire and distribute iron needed for oxygen-based metabolism. PLoS Biol. 1: 326-328. 2. Giannetti, A.M. et al. (2003) Mechanism for multiple ligand recognition by the human transferrin receptor. PLoS Biol. 1: 341-350. |
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