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| Catalog Code: | NB100-627SS |
| Product Name: | VEGFR2 Antibody |
| Product Description: | Rabbit Polyclonal anti-VEGFR2, Sample Size |
| Clonality: | Polyclonal |
| ListPrice: | 100 |
| Immunogen: | This antibody was made to residues corresponding to the kinase insert or C-terminus of murine VEGFR-2 (residues 1158-1365). |
| Specificity: | This antibody is specific for VEGFR-2. |
| Cross Reactivity: | This antibody reacts with mouse and human VEGFR-2 proteins. Other species have not been tested. |
| Packaging: | 0.025 ml Whole antisera Rabbit antisera. |
| Uses: | This antibody has been tested in Western blot on CSF-1/VEGFR2 transfected lysates and immunoprecipitation. It has not been tested in any other application.*Suggested working dilutions:Western Blot: 1:2,000-1:10,000 (ECL)Immunoprecipitation: 2-5 ul*Optimal working dilutions should be determined by the investigator. |
| Background: | VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signaling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Rabbit |
| Application Summary: | Western Blot, immunoprecipitation |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-VEGFR2 antibody, anti-VEGFR 2 antibody, anti-Protein-tyrosine kinase receptor flk-1 antibody, anti-Fetal liver kinase 1 antibody, anti-Kinase NYK antibody, anti-FLK1 antibody, anti-KDR antibody, anti-Kinase insert domain receptor antibody, anti-KRD1 antibody, anti-Ly73 antibody, anti-Protein tyrosine kinase receptor FLK1 antibody, anti-Vascular endothelial growth factor receptor 2 antibody |
| Package Size: | 0.025 ml |
| Preservative: | Sodium Azide |
| Product References: | 1. Rahimi, N., et al. Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. JBC, 275(22): 16986-16992, 2000. (Porcine, Western Blot, Immunoprecipitation) 2. Meyer, RD., et al. The carboxyl terminus controls ligand-dependent activation of VEGFR-2 and its signaling. JBC, 279(1): 735-742, 2004. (Porcine, Western Blot, Immunoprecipitation) 3. Singh, A.J., et al. The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. Mol. Biol. Cell 16:2106-2118, 2005. (Porcine, Western Blot, Immunoprecipitation) |
| Novus References: | 1. Puglisi F, Puppin C, Pegolo E, et al. Expression of periostin in human breast cancer. J Clin Pathol. April 1, 2008;61(4):494-8. |
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