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| Catalog Code: | NB100-62617 |
| Product Name: | GRANZYME B Antibody |
| Product Description: | Mouse Monoclonal anti-GRANZYME B (GB10), conjugated to Biotin |
| Clone: | GB10 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Purified human Granzyme B |
| Specificity: | Recognises the serine protease Granzyme B, which is expressed within the granules of cytolytic lymphocytes (CTLs). Granzyme B plays a key role in the induction of apoptosis by CTLs. After delivery to the target cell Granzyme B activates the cascade of caspases that finally results in cell death. This antibody has been reported to function as a detection reagent in ELISA assays for soluble Granzyme B in conjunction with GB11 as capture reagent. |
| Cross Reactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Mouse ascites. |
| Uses: | This antibody is useful for ELISA |
| Localization: | Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells |
| Background: | Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | Phosphate buffered saline |
| Application Summary: | ELISA |
| Species Summary: | Hu |
| Alternate Names: | Anti-C11 antibody, Anti-Cathespin G Like 1 antibody, Anti-CCPI antibody, Anti-CGL 1 antibody, Anti-CGL1 antibody, Anti-CSP B antibody, Anti-CSPB antibody, Anti-CTLA 1 antibody, Anti-CTLA1 antibody, Anti-CTSGL 1 antibody, Anti-CTSGL1 antibody, Anti-Cytotoxic serine protease B antibody, Anti-Cytotoxic T Lymphocyte Associated Serine Esterase 1 antibody, Anti-Cytotoxic T lymphocyte proteinase 2 antibody, Anti-EC 3.4.21.79 antibody, Anti-Fragmentin 2 antibody, Anti-Fragmentin2 antibody, Anti-Granzyme 2 antibody, Anti-Granzyme2 antibody, Anti-GranzymeB antibody, Anti-GRB antibody, Anti-GZMB antibody, Anti-HLP antibody, Anti-Human lymphocyte protein antibody, Anti-Lymphocyte protease antibody, Anti-Protease Serine B antibody, Anti-SECT antibody, Anti-T cell serine protease 1 3E antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.001% Thiomersal |
| Conjugate: | Biotin |
| General References: | 1. Spaeny-Dekking, E. H. A. et al. (1998) Extracellular Granzymes A and B in humans: Detection of native species during CTL responses in vitro and in vivo. J. Immunol. 160: 3610 - 3616. |
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