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| Catalog Code: | NB100-62598 |
| Product Name: | GLUCOCORTICOID RECEPTOR Antibody |
| Product Description: | Sheep Polyclonal anti-GLUCOCORTICOID RECEPTOR |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 13.26 mg/ml |
| Immunogen: | Synthetic peptide corresponding to the amino acids 151 - 164 of the native molecule conjugated to Keyhole limpet Haemocyanin. |
| Epitope: | P-T-E-K-E-F-P-L-T-H-S-D-V-S |
| Specificity: | Other antibodies raised to sequences in this area are reactive with both activated and unactivated forms of the receptor and have given predominantly cytoplasmic staining before activation and predominantly nuclear staining after activation. |
| Cross Reactivity: | Based on sequence similarity, is expected to react with:Human, Rat |
| Packaging: | 1 ml of Ammonium Sulphate fractionation Purified IgG |
| Uses: | This antibody is useful for ELISA |
| Localization: | Cytoplasmic in the absence of ligand; nuclear after ligand-binding. |
| Background: | Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocoticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain glucocorticoid receptor. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Sheep |
| Buffer: | Phosphate buffered saline, pH7.2 |
| Application Summary: | ELISA |
| Species Summary: | Hu |
| Alternate Names: | anti-GCCR antibody, anti-GCR antibody, anti-Glucocorticoid receptor lymphocyte antibody, anti-GR antibody, anti-GRL antibody, anti-Grl1 antibody, anti-NR3C1 antibody, anti-Nuclear receptor subfamily 3 group C member 1 antibody |
| Package Size: | 1 ml |
| Preservative: | 0.09% Sodium Azide (NaN3) |
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more information: | company product webpage |