| CatalogCode: | NB100-62592 |
| ProductName: | GELSOLIN Antibody |
| Product Description: | Sheep Polyclonal anti-GELSOLIN |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to the amino acids 729 - 742 of the native molecule conjugated to Keyhole limpet Haemocyanin.Peptide sequence: FVGWFLGWDDDYWS |
| Epitope: | FVGWFLGWDDDYWS |
| Specificity: | NB100-62592 is specifc for human gelsolin and reacts with both the plasma and cytoplasmic forms.Gelsolin is a calcium and polyphosphoinositide regulated actin-binding protein which consists of 6 homologous domains. It is involved in cell morphology, motility, growth and apoptosis through its ability to affect filament assembly by severing actin filaments, forming a nucleus for polymerisation, and capping the fast exchanging end of the filaments.It exists as an intracellular form, found in the cytoplasm and mitochondria, and an extracellular form located in blood plasma. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 1 ml protein G purified Sheep IgG. |
| Uses: | This antibody is useful for ELISA |
| Background: | Gelsolin is a calcium dependent actin binding protein. It is a potent modulator of actin filament length and gelation. Gelsolin has been shown to exist in at least two variant forms, cytoplasmic gelsolin and plasma gelsolin. Plasma gelsolin has also been called actin depolymerizing factor (ADF) or brevin. Human plasma and rabbit macrophage gelsolins differ by the presence of a 25 amino acid residue extension at the NH2 terminus in the human plasma gelsolin which appears to account for the difference in relative molecular weights. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Sheep |
| Buffer: | Phosphate buffered saline, pH7.2 |
| ListPrice: | 285 |
| AppSummary: | ELISA |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Actin depolymerizing factor antibody, anti-ADF antibody, anti-AGEL antibody, anti-Amyloidosis Finnish type antibody, anti-Brevin antibody, anti-DKFZp313L0718 antibody, anti-GSN antibody |
| ProteinTarget: | GELSOLIN |
| PackageSize: | 1 ml |
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