| CatalogCode: | NB100-62578 |
| ProductName: | FOLATE BINDING PROTEIN Antibody |
| Product Description: | Mouse Monoclonal anti-FOLATE BINDING PROTEIN (SF99 (BGN/1210/99)) |
| Clone: | SF99 (BGN/1210/99) |
| Clonality: | Monoclonal |
| Immunogen: | Folate binding protein from bovine milk |
| Specificity: | NB100-62578 reacts with folate binding protein (FBP) a 30 kDa protein with a high affinity for folate and several reduced folic acid derivatives, that mediates the intracelullar delivery of 5 methyltetrahydrofolate. Membrane bound and soluble forms of a high affinity FBP have been found in kidney, placenta, serum, milk, and several cell lines. |
| Packaging: | 0.2 mg protein A purified Mouse ascites. |
| Uses: | This antibody is useful for ELISA |
| Localization: | Cell Membrane; lipid-anchor; GPI-anchor. Secreted protein |
| Background: | Folate Binding Protein, has a high affinity for folic acid and for several reduced folic acid derivatives and mediates delivery of 5 methyltetrahydrofolate to the interior of cells. Membrane bound and soluble forms of a high affinity folate binding protein have been found in kidney, placenta, serum, milk, and in several cell lines. The 2 forms have similar binding characteristics for folates, are immunologically crossreactive, and, based upon limited amino acid sequence data, are nearly identical. There may be a precursor product relationship between the membrane and soluble forms, the membrane form having additional amino acid residues and greater molecular weight. The membrane form has been shown to mediate the transport of folate in cells grown in physiologic concentrations of folate. A function for the soluble form, which is found in serum, milk, and urine, has not been identified. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | ELISA |
| SpeciesSummary: | Bv |
| ALTnames: | anti-Adult folate binding protein antibody, anti-FBP antibody, anti-Folate Receptor 1 Adult antibody, anti-Folate receptor 1 antibody, anti-Folate Receptor 1 Precursor antibody, anti-Folate receptor alpha antibody, anti-FOLR antibody, anti-FOLR1 antibody, anti-FR alpha antibody, anti-FRalpha antibody, anti-KB cells FBP antibody, anti-MOV18 antibody, anti-Ovarian cancer associated antigen antibody, anti-Ovarian tumor associated antigen antibody, anti-Ovarian tumor associated antigen MOv18 antibody |
| ProteinTarget: | FOLATE BINDING PROTEIN |
| PackageSize: | 0.2 mg |
| GeneralRef: | 1. Henderson, G.B. (1990) Folate Binding Proteins Ann. Rev. Nutr. 10: 319-335. 2. Jones, M.L. and Nixon, P.F. (2002) Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein. J Nutr. 132:2690-2694. |
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