| CatalogCode: | NB100-62268 |
| ProductName: | CD161 Antibody |
| Product Description: | Mouse Monoclonal anti-CD161 (28764) |
| Clone: | 28764 |
| Clonality: | Monoclonal |
| Immunogen: | Purified splenic NK cells from the LEW rat strain. |
| Specificity: | NB100-62268 recognises the rat CD161 protein (also known as NKR-PI) a 60kD glycoprotein expressed on rat NK cells and T cell subpopulations. This antibody competes with clone 3.2.3 for binding to antigen. |
| CrossReactivity: | Rat. Not yet tested in other species. |
| Packaging: | 0.25 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, Western Blot, flow cytometry / FACS analysis, immunoprecipitation, Radioimmunoassays |
| Localization: | Cell Membrane |
| Background: | Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 (CD161) protein contains an extracellular domain with several motifs characteristic of C type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. In mouse the NKRP1 family has three members, NKRP1A, B and C, whilst in human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, b and c. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline pH7.4 |
| ListPrice: | 285 |
| AppSummary: | FACS, IP, WB, IHC-Fr, RIA |
| SpeciesSummary: | Rt |
| ALTnames: | anti-CLEC5B antibody, anti-Killer Cell Lectin like Receptor Subfamily B Member 1 antibody, anti-KLRB1 antibody, anti-NKR antibody, anti-NKRP1 antibody, anti-NKRP1A antibody |
| ProteinTarget: | CD161 |
| PackageSize: | 0.25 mg |
| GeneralRef: | 1. Sedgwick, J.D. et al. (1998) Central Nervous system microglial cell activation and proliferation follows direct interation with Tissue-infiltrating T Cell Blasts. J. Immunol. 160: 5320-5330. 2. Tliba, O. et al. (2002) Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats. Vet. Res. 33(3):327-32. |
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