| CatalogCode: | NB100-62173 |
| ProductName: | THYROXINE BINDING GLOBULIN Antibody |
| Product Description: | Sheep Polyclonal anti-THYROXINE BINDING GLOBULIN |
| Clonality: | Polyclonal |
| Immunogen: | Human thyroxine binding globulin purified from serum |
| Specificity: | NB100-62173 recognises Thyroxine Binding Globulin (TBG), a serpin produced in the liver with high affinity for the thyroid hormones T3 and T4. TBG reversibly binds T3 and T4, enabling their circulation around the bloodstream. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 1 ml of Purified IgG |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, Immunodiffusion |
| Background: | Thyroxine Binding Globulin (TBG) is one of three proteins responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3 triiodothyronine (T3) in the bloodstream, along with transthyretin and albumin. TBG has the highest affinity for T4 and T3, but is present in the lowest concentration of the three proteins. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 & T3, TBG is rarely more than 25% saturated with ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. Genomically, TBG is a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG is synthesized primarily in the liver. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Sheep |
| Buffer: | Glycine buffered saline, pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | IHC-Fr, ID |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Serpin A7 antibody, anti-Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 antibody, anti-SERPINA7 antibody, anti-T4 binding globulin antibody, anti-TBG antibody |
| ProteinTarget: | THYROXINE BINDING GLOBULIN |
| PackageSize: | 1 ml |