| CatalogCode: | NB100-62135 |
| ProductName: | TAFI Antibody |
| Product Description: | Mouse Monoclonal anti-TAFI (19-E3) |
| Clone: | 19-E3 |
| Clonality: | Monoclonal |
| Immunogen: | Human TAFI |
| Specificity: | NB100-62135 detects Thrombin Activatable Fibrinolysis Inhibitor (TAFI), a basic carboxypeptidase zymogen which is formed in the liver and circulates in the blood. TAFI is activated during blood clotting by the thrombin-thrombomodulin complex, forming TAFIa. TAFIa cleaves carboxy-terminal lysine residues from partially degraded fibrin to attenuate fibrinolysis.TAFI may also function in the regulation of inflammation, wound healing and blood pressure. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.2 mg protein A purified Mouse ascites. |
| Uses: | This antibody is useful for ELISA, Western Blot, Immunoassay |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | ELISA, WB, IA |
| SpeciesSummary: | Hu |
| ProteinTarget: | TAFI |
| PackageSize: | 0.2 mg |
| GeneralRef: | 1. Boffa, M.B. and Koschinsky, M.L. (2007) Curiouser and curiouser: recent advances in measurement of thrombin-activatable fibrinolysis inhibitor (TAFI) and in understanding its molecular genetics, gene regulation, and biological roles. Clin Biochem. 40: 431-442. 2. Bajzar, L. (2000) Thrombin activatable fibrinolysis inhibitor and an antifibrinolytic pathway. Arterioscler. Thromb. Vasc. Biol. 20: 2511-2518. 3. Boffa, M.B. et al. (2001) Thrombin activable fibrinolysis inhibitor (TAFI): molecular genetics of an emerging potential risk factor for thrombotic disorders. Curr. Drug Targets Cardiovasc. Haematol. Disord. 1: 59-74. |
| NotesMain: | Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line. Western Blotting: Detects a band of approximately 58kDa when using purified human TAFI. |