| CatalogCode: | NB100-613 |
| ProductName: | FOXO3A Antibody |
| Product Description: | Rabbit Polyclonal anti-FOXO3A |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide mapping to a region between residues 250 and 300 of human Forkhead Box O3a using the numbering given in Swiss-Prot entry O43524 (GeneID 2309). |
| Specificity: | NB 100-613 is specific for human FOXO3a protein. |
| CrossReactivity: | Human. Other species have not been tested. Reactivity with mouse FOXO3a is expected owing to complete identity of sequence between this ortholog and human FOXO3a at the site to which the epitope maps. Reactivity with Drosophila melanogaster is not likely. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | Western Blot: 1:5,000 - 1:15,000Immunoprecipitation: 2 to 5 ug/mg lysate Histo/Cytochemistry: not tested*In some cases, the antibody may be diluted further than indicated. |
| Background: | The FOXO3 gene is known to promote longevity in animals and has now been discovered to encode a tumor suppressor. The new gene, which was inactivated in two-thirds of patients studied, presents a potent new target for breast cancer. The protein, named Forkhead box class O3 (FOXO3), is associated with better outcomes for breast cancer patients. Conversely, if FOXO3 was inactivated, patients had worse outcomes. FOXO3 is inactivated in many cancer patients by an enzyme called IKK, which is an oncoprotein. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 0.02% Sodium Azide Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4 |
| ListPrice: | 300 |
| AppSummary: | WB, IP |
| SpeciesSummary: | Dr(-), Hu |
| ALTnames: | anti-AF6q21 antibody, anti-FKHR2 antibody, anti-FKHRL1 antibody, anti-FKHRL1P2 antibody, anti-Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1 antibody, anti-DAF16 antibody |
| ProteinTarget: | FOXO3a antibody |
| PackageSize: | 0.1 ml |
| NotesMain: | Blocking peptide is available or can be made for this item. Lead time is 3 days to 4 weeks. Price is $ 150/0.25 ml (or 50 ug). Please enquire availability. |
| Gene_Id: | 2309 |
| Omim_ID: | NB100-614 |
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