| CatalogCode: | NB100-60557 |
| ProductName: | PSME3 Antibody |
| Product Description: | Goat Polyclonal anti-PSME3 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, C-KNIEKIKRPRSSN, representing the C Terminus of the sequence according to NP_005780.2; NP_789839.1 |
| Epitope: | KNIEKIKRPRSSN |
| CrossReactivity: | Human. Other species not tested. Expected based upon sequence homology: Mouse, Rat, Dog |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 132,000.Western Blot: Approx 30kDa band observed in lysates of cell lines Jurkat and K562 (calculated MW of 29.5kDa according to NP_005780.2 and 30.9kDa according to NP_789839.1). Recommended concentration: 0.1-0.3ug/ml. |
| Control: | K562 cell lysate |
| Background: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-PSME3 antibody, anti-proteasome (prosome, macropain) activator subunit 3 antibody, anti-Ki antibody, anti-PA28-gamma antibody, anti-PA28G antibody, anti-REG-GAMMA antibody, anti-11S regulator complex gamma subunit antibody, anti-Ki antigen antibody, anti-Ki nuclear autoantigen antibody, anti-activator of multicatalytic protease subunit 3 antibody, anti-proteasome activator 28-gamma antibody, anti-proteasome activator subunit 3 antibody |
| ProteinTarget: | PSME3 |
| PackageSize: | 0.1 mg |
| Homology: | Human, Mouse, Rat, Dog |
| GeneralRef: | Matsudaira R, et al. Relationships between autoantibody responses to deletion mutants of Ki antigen and clinical manifestations of lupus. J Rheumatol. 2003 Jun;30(6):1208-14. PMID: 12784391 |
| NotesMain: | GeneIDs all Nonhuman: 19192 (mouse); 287716 (rat); This antibody is expected to recognise both reported isoforms (NP_005780.2 and NP_789839.1). |
| Gene_Id: | 10197 |
| Gene_Symbol: | PSME3 |
| Ref_Sqnce: | NP_005780.2; NP_789839.1 |
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