| CatalogCode: | NB100-60545 |
| ProductName: | SREBP1 Antibody |
| Product Description: | Rabbit Polyclonal anti-SREBP1 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide made to a portion of the human SREBP1 protein sequence (between residues 700-800). [Uniprot# P36956] |
| CrossReactivity: | Human. May react with mouse. No other species have been tested. |
| Packaging: | 0.1 ml peptide affinity purified Rabbit antisera. |
| Uses: | By Western blot a band is seen at ~65 kDa (mature form). |
| Localization: | Integral membrane protein that moves from ER to Golgi in absence of sterols. |
| Control: | Human liver lysate |
| Background: | SREBP (Sterol Regulatory Element Binding Protein) 1 and 2 are transcription factors which participate in the control of cholesterol homeostasis. SREBP proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. SREBPs may also play some role in the apoptotic processes. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | peptide affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-glycine, 150 mM NaCl |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-Sterol regulatory element binding protein 1 antibody, anti-SRBP1 antibody, anti-Sterol regulatory element-binding transcription factor antibody |
| PackageSize: | 0.1 ml |
| Homology: | 100% homology with mouse, rat, and hamster proteins. 70% homology with chicken protein. |
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