| CatalogCode: | NB100-60422 |
| ProductName: | TBP Antibody |
| Product Description: | Rabbit Polyclonal anti-TBP |
| Clonality: | Polyclonal |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 1 and 50 of human TATA box binding protein using the numbering given in entry NP_003185.1 (GeneID 6908). |
| CrossReactivity: | Human. Other species not yet tested. |
| Packaging: | 0.1 mg of antigen affinity purified antisera. |
| Uses: | This antibody is useful for Western Blot analysis. It is not recommended for Immunoprecipitation. |
| Background: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer [ pH 7 to 8] |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-TBP antibody, anti-TATA box binding protein antibody, anti-SCA17 antibody, anti-SCA-17 antibody, anti-spinocerebellar ataxia 17 antibody, anti- TF2D antibody, anti-TFIID antibody, anti-Transcription initiation factor TFIID TBP subunit antibody |
| ProteinTarget: | TBP |
| PackageSize: | 0.1 mg |
| Gene_Id: | 6908 |
| Omim_ID: | NB500-700 |