| CatalogCode: | NB100-592 |
| ProductName: | ROCK2 Antibody |
| Product Description: | Rabbit Polyclonal anti-ROCK2 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide mapping to a region between residues 1 and 100 of human Rho Kinase alpha using the number given in entry NP_004841.1 (GeneID 9475). |
| Specificity: | NB 100-592 is specific for human Rho Kinase alpha protein. |
| CrossReactivity: | Human. Other species have not been tested. Reactivity with mouse Rho Kinase alpha is likely owing to high similarity between this ortholog and human Rho Kinase alpha at the epitope that is recognized by NB 100-592. |
| Packaging: | 0.1 ml protein A purified Rabbit antisera. |
| Uses: | Optimal working dilutions should be determined experimentally by the investigator. Prepare working dilution immediately before use. Suggested starting dilutions are as follows. Western Blot: 1:10,000 - 1:25,000 Immunoprecipitation: 2 to 5 ug/mg of lysate Histo/Cytochemistry: not tested *In some cases, the antibody may be diluted further than indicated. |
| Background: | The small GTPase Rho is implicated in cytoskeletal rearrangements including stress fiber and focal adhesion formation and in the transcriptional activation of c-fos serum response element. In vitro, Rho-kinase, which is activated by Rho, phosphorylates not only myosin light chain (MLC) (thereby activating myosin ATPase) but also myosin phosphatase, thus inactivating myosin phosphatase. Rho-kinase is involved in the formation of stress fibers and focal adhesions in fibroblasts. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein A purified |
| Host_Name: | Rabbit |
| Buffer: | BSA, 10mM PBS, pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | WB, IP |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Rho Kinase antibody, anti-ROCK2 antibody, anti-ROCK-2 antibody, anti-ROCKII antibody, anti-ROCK-II antibody, anti-Rho-associated antibody, anti-coiled-coil containing protein kinase 2 antibody, anti-ROK-alpha antibody, anti-Rho Kinase Alpha antibody, anti-KIAA0619 antibody, anti-Rho Kinase alpha antibody |
| ProteinTarget: | Rho Kinase Alpha antibody |
| PackageSize: | 0.1 ml |
| NotesMain: | Blocking peptide is available or can be made for this item. Lead time is 3 days to 4 weeks. Price is $ 150/0.25 ml (or 50 ug). Please enquire availability. |
| Gene_Id: | 9475 |
| Omim_ID: | NB100-593 |
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