| CatalogCode: | NB100-58959 |
| ProductName: | TRAF2 Antibody |
| Product Description: | Goat Polyclonal anti-TRAF2 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide, C-KMEAKNSYVRDD, representing the C Terminus of the sequence according to NP_066961.2 |
| Epitope: | KMEAKNSYVRDD |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:128,000.Western Blot: Approx 50kDa band observed in Human Ovary lysates (calculated MW of 55.9kDa according to NP_066961.2). Recommended concentration: 0.1-0.3ug/ml. |
| Background: | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline [ pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-TRAF2 antibody, anti-TNF receptor-associated factor 2 antibody, anti-MGC:45012 antibody, anti-TRAP antibody, anti-TRAP3 antibody, anti-OTTHUMP00000064745 antibody, anti-tumor necrosis factor type 2 receptor associated protein 3 antibody |
| ProteinTarget: | TRAF2 |
| PackageSize: | 0.1 mg |
| Homology: | Human, Mouse, Rat, Dog |
| GeneralRef: | Xu Y, Huang S, Liu ZG, Han J. Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem. 2006 Jan 30; [Epub ahead of print] PMID: 16446354 |
| NotesMain: | Other Gene ID: 22030 (mouse); |
| Gene_Id: | 7186 |
| Gene_Symbol: | TRAF2 |
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