| CatalogCode: | NB100-58798 |
| ProductName: | SHARP Antibody |
| Product Description: | Rabbit Polyclonal anti-SHARP |
| Clonality: | Polyclonal |
| Immunogen: | Antibody was affinity purified using an epitope specific to SHARP immobilized on solid support.The epitope recognized by this antibody maps to a region between residue 1350 and 1400 of human SMART/HDAC1 associated repressor protein (spen homolog, transcriptional regulator) using the numbering given in entry NP_055816.2 (GeneID 23013). |
| CrossReactivity: | Human. No other species have been tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | Western Blot - Not recommended for crude preparations. It can be used successfully for WB of enriched preparations (e.g. immunoprecipitated) SHARP. Immunoprecipitation - 2 to 5 mcg/mg lysate. Immunohisto-/cytochemistry - Not tested. |
| Background: | This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| ListPrice: | 325 |
| AppSummary: | WB, IP |
| SpeciesSummary: | Hu |
| ALTnames: | anti-SHARP antibody, anti-SMART/HDAC1 associated repressor protein antibody, anti-SPEN antibody, anti-spen homolog antibody, anti-transcriptional regulator antibody, anti-MINT antibody, anti-Msx2 interacting nuclear target antibody, anti-KIAA0929 antibody |
| ProteinTarget: | SHARP |
| PackageSize: | 0.1 mg |
| Gene_Id: | 23013 |
| Gene_Symbol: | SPEN |
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