| CatalogCode: | NB100-58752 |
| ProductName: | PAEL Receptor (GPR37) Antibody |
| Product Description: | Rabbit Polyclonal anti-PAEL Receptor (GPR37) |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide - KLH conjugated |
| Epitope: | N-terminal extracellular domain of human protein |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.05 mg of antigen affinity purified antisera |
| Uses: | Immunohistochemistry (Paraffin-embedded sections): Recommended starting dilution 20 µg/ml |
| Control: | Brain |
| Background: | GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 350 |
| AppSummary: | IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-EDNRBL antibody, anti-ETBR-LP-1 antibody, anti-GPR37 antibody, anti-HET(B)R-LP antibody, anti-PAELR antibody |
| ProteinTarget: | PAEL Receptor (GPR37) |
| PackageSize: | 0.05 mg |
| Homology: | Mouse (Identity: 44% Similarity: 56%), Rat (Identity: 44% Similarity: 69%) |
| Gene_Id: | 2861 |
| Gene_Symbol: | GPR37 |