| CatalogCode: | NB100-56759 |
| ProductName: | IL-28 Ra Antibody |
| Product Description: | Rabbit Polyclonal anti-IL-28 Ra |
| Clonality: | Polyclonal |
| Immunogen: | Amino acids 232-244 of human IL-28 receptor alpha protein were used as the immunogen. |
| Specificity: | The NCBI accession number for IL-28RA is NP_775088. This antibody is specific for isoform 3 of IL-28RA, which is a 244 amino acid protein. |
| CrossReactivity: | Cross reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 ml Whole Rabbit antisera. |
| Control: | Yet to be identified |
| Background: | IL28 is a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Rabbit sera with 50% glycerol |
| ListPrice: | 295 |
| AppSummary: | ELISA |
| SpeciesSummary: | Hu |
| ALTnames: | anti-IL-28 receptor alpha antibody, anti-IL-28RA antibody |
| ProteinTarget: | IL-28 Ra |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Dumoutier,L., Lejeune,D., Hor,S., Fickenscher,H. and Renauld,J.C. Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3 Biochem. J. 370 (Pt 2), 391-396 (2003) 2. Kotenko,S.V., Gallagher,G., Baurin,V.V., Lewis-Antes,A., Shen,M., Shah,N.K., Langer,J.A., Sheikh,F., Dickensheets,H. and Donnelly,R.P. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex Nat. Immunol. 4 (1), 69-77 (2003) 3. Sheppard,P., Kindsvogel,W., Xu,W., Henderson,K., Schlutsmeyer,S., Whitmore,T.E., Kuestner,R., Garrigues,U., Birks,C., Roraback,J., Ostrander,C., Dong,D., Shin,J., Presnell,S., Fox,B., Haldeman,B., Cooper,E., Taft,D., Gilbert,T., Grant,F.J., Tackett,M., Krivan,W., McKnight,G., Clegg,C., Foster,D. and Klucher,K.M. IL-28, IL-29 and their class II cytokine receptor IL-28R Nat. Immunol. 4 (1), 63-68 (2003). |
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