| Catalog Code: | NB100-56749 |
| Product Type: | Primary Antibody |
| Product Name: | AKT1 Antibody |
| List Price: | 295 |
| Clonality: | Monoclonal |
| Gene ID: | 207 |
| Host: | Mouse |
| Clone: | 104A282 |
| Isotype: | IgG1, k |
| Product Description: | Mouse Monoclonal anti-AKT1 (104A282) [Ser473] |
| Phosphorylated: | Ser473 |
| Cross Reactivity: | Human, Mouse Predicted to cross-react with Frog and Chicken. Not yet tested in other species. |
| Species Summary: | Hu, Mu |
| Background: | Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The ma |
| Immunogen: | This monoclonal antibody was raised against a synthetic peptide containing phosphorylated serines at amino acid residues 473 of human Akt1. The sequence in this region is identical in human, mouse, chicken, and frog. |
| Specificity: | Clone 104A282 detects specifically phosphorylated form of Akt1 expression in PDGF treated cells. |
| Purity: | protein G purified |
| Buffer: | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Package Size: | 0.1 mg |
| Concentration: | 0.5 mg/ml |
| Application Summary: | IP, WB |
| General References: | 1. Alessi DR., et al. EMBO J. 15: 6541-6551 (1996). 2. Ferring P., et al. Oncogene 18: 6129-6134 (1999). 3. Kandel ES, et al. Exp. Cell Res. 253: 210-219 (1999). 4. Cantley LC, et al. Proc Natl Acad Sci, USA, 96: 420-4245 (1999). 5. Franke TF, et al. C |
| Product References: | 1. Deguelin, an Akt Inhibitor, Suppresses IB Kinase Activation Leading to Suppression of NF-kB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion. Asha S. Nair, Shishir Shishodia, Kwang Seok Ahn, Ajaikumar B. Kunnuma |
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