| CatalogCode: | NB100-56745 |
| ProductName: | Nak-1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Nak-1 |
| Clonality: | Polyclonal |
| Immunogen: | This antibody was developed against a synthetic peptide corresponding to aa 251-266 of human Nak1. It will cross-react with mouse Nak1. |
| Specificity: | An 84 kDa band is observed. |
| CrossReactivity: | Cross reacts with Human and Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Rabbit antisera. |
| Control: | MOLT-4 or NIH 3T3 |
| Background: | Nak1 is a member of the steroid/thyroid hormone receptor superfamily. The gene for Nak-1 is induced rapidly by androgens/growth factors and may have functions related to cell proliferation, differentiation and apoptosis (1). Liu et al (2) have demonstrated that mouse nur77 is necessary for induced apoptosis in T-cell hybridomas and can also be induced during early mitogenesis. Nak1 is a phosphoprotein and its size ranges from 67 kD to 88 kD, depending on post-translational modifications. |
| ProductRef: | 1. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl) methanes induces apoptosis through nuclear pathways. Sudhakar Chintharlapalli, Robert Burghardt, Sabitha Papineni, Shashi Ramaiah, Kyungsil Yoon, and Stephen Safe. J. Biol. Chem., 280: 24903-24914 (2005). (ICC & WB) |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | IF, WB, ICC |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-Nur77 antibody, anti-Tr3 antibody, anti-NR4A1 antibody, anti-Nak1 antibody |
| ProteinTarget: | Nak-1 |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Nakai, A., et al., A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. Mol. Endocrinol. 4 (10), 1438-1443 (1990). |