| CatalogCode: | NB100-56729 |
| ProductName: | PGRP-1a Antibody |
| Product Description: | Mouse Monoclonal anti-PGRP-1a (187C434) |
| Clone: | 187C434 |
| Clonality: | Monoclonal |
| Immunogen: | This antibody was developed against KLH-conjugated synthetic peptide corresponding to amino acids 178-193 of human PGRP-1a . |
| CrossReactivity: | Human Not yet tested in other species. |
| Packaging: | 0.2 ml Ascites Mouse ascites. |
| Uses: | WB: 1:500-1:1000~; Flow: (see Uehara et al, 2005)~; IF/ICC: (see Uehara et al, 2005)~; |
| Background: | Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia , and PGRP-Iß) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-1a mRNA is highly expressed in esophagus, tonsils and thymus and to lesser extent in the stomach, rectum, and brain. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | FACS, IF, ICC, WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | PGRP-1a |
| PackageSize: | 0.2 ml |
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