| CatalogCode: | NB100-56664 |
| ProductName: | SET7/9 Antibody |
| Product Description: | Rabbit Polyclonal anti-SET7/9 |
| Clonality: | Polyclonal |
| Immunogen: | Two synthethic peptides corresponding to amino acids 131-145 ([BLAST]GEVNEDGEMTGEKIA[/BLAST]) and 336-352 ([BLAST]GYDHSPPGKSGPEAPEW[/BLAST]) of human Set7/9 were used as immunogen; GenBank Accession No. NP_085151.1. These sequences are 100% conserved between human, mouse and rat. |
| Specificity: | This antibody, IMG-587, is specific for Set7/9 (a histone H3 lysine 4 methyltransferase) and does not recognize PR-Set7 (a histone H4 lysine 20 methyltransferase). |
| CrossReactivity: | Mouse, Human Not yet tested in other species. |
| Packaging: | 0.2 ml Whole antisera Rabbit antisera. |
| Uses: | WB: 1:500-1:1000 |
| Background: | Diverse signal transduction pathways impinging on the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. Human Set7/9 is a 336 amino acid protein. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ProteinTarget: | Set7/9 |
| PackageSize: | 0.2 ml |
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