| CatalogCode: | NB100-56654 |
| ProductName: | TRAF3 Antibody |
| Product Description: | Rabbit Polyclonal anti-TRAF3 |
| Clonality: | Polyclonal |
| Immunogen: | A peptide corresponding to amino acids 323-340 of human TRAF3 was used. |
| Specificity: | A 67 kDa band is observed. |
| CrossReactivity: | Human, Mouse. Not yet tested in other species. |
| Packaging: | 0.2 ml protein G purified Rabbit antisera. |
| Control: | HeLa or NIH 3T3 |
| Background: | Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor-associated factors. TRAF3 binds only a single site, which contains the sequence PEQET, whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-TRAF-3 antibody, anti-TNF receptor associated protein 3 antibody |
| ProteinTarget: | TRAF3 |
| PackageSize: | 0.2 ml |
| GeneralRef: | 1. Cheng G, et al. Science 267:1494-8 (1995) 2. Baker SJ and Reddy EP. Oncogene 12:1-9 (1996). |