| CatalogCode: | NB100-56642 |
| ProductName: | PRMT6 Antibody |
| Product Description: | Rabbit Polyclonal anti-PRMT6 |
| Clonality: | Polyclonal |
| Immunogen: | This antibody was developed against a mixture of synthetic peptides corresponding to human PRMT6 amino acid sequence. HeLa cell lysate (IMGENEX, cat. no. 40161) can be used as positive control. This antibody also cross reacts with mouse cell line (RAW). |
| CrossReactivity: | Human, Mouse Not yet tested in other species. |
| Packaging: | 0.2 ml of Rabbit Affinity Purified |
| Uses: | WB: 1:500-1:1000 |
| Control: | HeLa or RAW |
| Background: | Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT6 was identified by searching the human genome for protein arginine N-methyltransferase (PRMT) family members. PRMT6 cDNA codes for a protein of approximate molecular weight of 42 kDa consisting of a catalytic core sequence common to other PRMT enzymes. PRMT6 demonstrates type I PRMT activity, capable of forming both >NG-monomethylarginine and asymmetric >NG,NG-dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. A comparison of substrate specificity reveals that PRMT6 is functionally distinct from two previously characterized type I enzymes, PRMT1 and PRMT4. In addition to methylating substrate proteins, PRMT6 displays automethylation activit. GFP-fusion protein expression in the transfected cell lines suggest that PRMT6 localizes in the nucleus. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide and 0.1 mg/ml BSA. Sodium azide is highly toxi |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ProteinTarget: | PRMT6 |
| PackageSize: | 0.2 ml |
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