| CatalogCode: | NB100-56602 |
| ProductName: | Bad-cleaved Antibody |
| Product Description: | Rabbit Polyclonal anti-Bad-cleaved |
| Clonality: | Polyclonal |
| Immunogen: | This antibody was developed by immunizing rabbits with a synthetic peptide containing Asp61 (cleavage site) of Bad. |
| CrossReactivity: | Human Not yet tested in other species. |
| Packaging: | 0.1 mg Rabbit antisera. |
| Uses: | WB: 1:250-1:500 |
| Control: | TNF-a treated HeLa (10 ng/ml, 2 hr) |
| Background: | The function of Bad, a proapoptotic member of the Bcl-2 family, is regulated primarily by rapid changes in phosphorylation that modulate its protein-protein interactions and subcellular localization. Human Bad, which is 43 amino acids shorter than its mouse counterpart, is cleaved by a caspase upon exposure of Jurkat T cells to anti-FAS antibody, tumor necrosis factor alpha (TNF-alpha), or TRAIL. Moreover, a truncated form of human Bad lacking the N-terminal 28 amino acids is more potent than wild-type Bad in inducing apoptosis. Bad plays a novel and important role in maintaining the apoptotic phenotype in response to various apoptosis inducers. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS with 0.1 mg/ ml BSA and 0.02% Sodium azide. Sodium azide is highly toxic |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | BAD-cleaved |
| PackageSize: | 0.1 mg |