| CatalogCode: | NB100-56547 |
| ProductName: | IL-17B/E R Antibody |
| Product Description: | Mouse Monoclonal anti-IL-17B/E R (97C691) |
| Clone: | 97C691 |
| Clonality: | Monoclonal |
| Immunogen: | A recombinant protein of human IL-17BR was used as immunogen. |
| Specificity: | In HeLa, a 45 kDa band is observed. |
| CrossReactivity: | Human Not yet tested in other species. |
| Packaging: | 0.1 mg of Mouse Affinity Purified |
| Uses: | WB: 2 ug/ml |
| Background: | Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E (2). IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis (3), multiple sclerosis (4), and promotion of tumor growth (5). IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al (6) and Lee, et al. (2) and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain (2). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity Purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | IL-17B/E R |
| PackageSize: | 0.1 mg |
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