| CatalogCode: | NB100-56533 |
| ProductName: | STAM Antibody |
| Product Description: | Mouse Monoclonal anti-STAM (29C678) |
| Clone: | 29C678 |
| Clonality: | Monoclonal |
| Immunogen: | This antibody was developed against a synthetic peptide corresponding to amino acids 149-165 of human STAM. |
| Specificity: | A 59 kDa band is observed. |
| CrossReactivity: | Human Not yet tested in other species. |
| Packaging: | 0.1 mg of Mouse Affinity Purified |
| Uses: | WB: 1-2 ug/ml |
| Control: | 293 or HeLa |
| Background: | STAM is a signal transducing adaptor molecule, that contains an Src homology 3 (SH3) domain and immunoreceptor tyrosine-based activation motif (ITAM). STAM is associated with Jak3 and Jak2 tyrosine kinases via its ITAM region and phosphorylated by Jak3 and Jak2 upon stimulation with IL-2 and GM-CSF, respectively. An SH3 deletion mutant of STAM confers a dominant-negative effect on DNA synthesis mediated by IL-2 and GM-CSF. Furthermore, the wild-type STAM, but not STAM mutants deleted of SH3 and ITAM, significantly enhances c-myc induction mediated by IL-2 and GM-CSF. These results strongly implicate STAM in the signaling pathways for cell growth and c-myc induction immediately downstream of the Jaks associated with the cytokine receptors. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity Purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | STAM |
| PackageSize: | 0.1 mg |