| CatalogCode: | | NB100-56470 |
| ProductName: | | Chaperonin Antibody |
| Product Description: | | Rabbit Polyclonal anti-Chaperonin |
| Clonality: | | Polyclonal |
| Immunogen: | | A portion of amino acids 150-200 of human Hsp60 was used as the immunogen. |
| Specificity: | | The amino acid sequence used as immunogen is 100% homologous in a broad range of species including human, dog, mouse, rat, bovine, chimp, monkey, and orangutan. |
| CrossReactivity: | | Bovine, Broad, Chimpanzee, Dog, Human, Monkey Not yet tested in other species. |
| Packaging: | | 0.1 mg of Rabbit Affinity Purified |
| Uses: | | WB: 0.5-2 ug/ml |
| Background: | | Principal Names: 60KDa Chaperonin (CPN60); 60KDa Heat shock protein (HSP60); GROEL; Mitochondrial matrix protein P1; P60 lymphocyte protein; SPG13; HuCHA60; Official Gene Symbol: HSPD1 Gen Bank Accession Number: NP_002147 Gene ID: 3329 (Human) Gene Map Locus: 2q33.1 (Human) HSP60, a 60KDa member of Chaperonin family, is a mitochondrial protein that participates in protein folding, transport and secretion. HSP60 is a multi-functional protein whose roles include accelerating the maturation of pro-caspase 3 during apoptosis, LPS-binding, acting as a ligand for innate immune system and also binding to the surface of innate immune cells and stimulating proinflammatory reactivity. It induces the expression of IL-12 and IL-15 and also induces release of TNF-alpha, NO and IL-6. Reports suggest interaction of Hsp60 with integrin molecules during metastasis. Mutations in Hsp60 gene cause autosomal recessive spastic paraplegia 13. Hsp60 has been found to be involved in development of auto-immune disorders such as Rheumatoid arthritis, insulin-dependent diabetes mellitus, systemic sclerosis and atherosclerosis. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | Affinity Purified |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | | 295 |
| AppSummary: | | WB |
| SpeciesSummary: | | Bo, Mk, Ca, Hu |
| ALTnames: | | anti-Hsp60 antibody |
| ProteinTarget: | | Chaperonin |
| PackageSize: | | 0.1 mg |
| more information: | | company product webpage |
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