| CatalogCode: | NB100-56461 |
| ProductName: | CYLD Antibody |
| Product Description: | Rabbit Polyclonal anti-CYLD |
| Clonality: | Polyclonal |
| Immunogen: | A portion of amino acids 1-50 of human CYLD was used as the immunogen. |
| Specificity: | The amino acid sequence used is 100% homologous in human, mouse, chimpanzee, bovine and dog, and 92% homologous in rat. Human CYLD is a 956 amino acid protein and the approximate theoretical size is 105 kD. |
| CrossReactivity: | Bovine, Chimpanzee, Dog, Human, Mouse Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Rabbit antisera. |
| Background: | CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.2% gelatin |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Bo, Mk, Ca, Hu, Mu |
| ProteinTarget: | CYLD |
| PackageSize: | 0.1 mg |
order or
more information: | company product webpage |
| request information: |
|
|