| CatalogCode: | NB100-56450 |
| ProductName: | Nanog Antibody |
| Product Description: | Rabbit Polyclonal anti-Nanog |
| Clonality: | Polyclonal |
| Immunogen: | A portion of amino acids 1-50 of human Nanog was used as the immunogen. |
| CrossReactivity: | Chimpanzee, Goat, Human, Mouse, Rhesus Monkey Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Rabbit antisera. |
| Control: | HeLa, NIH 3T3 |
| Background: | Principal Names: Nanog; Cheester; Homeobox.1; Homeobox.3; FLJ12581; FLJ40451; Official Gene Symbol: NANOG Gene ID: 79923 (Human) Gene Map Locus: 12p13.31 (Human) NANOG is a unique variant of NK2 family of transcription factors. It is a human ortholog of mouse Nanog and consists of a highly conserved homeodomain and Trp-rich repeats. It is specifically expressed by embryonic stem cells and is crucial for second embryonic lineage determination. It works in concert with OCT-4 and SOX-2 and plays a central role in regulating pluripotency and self-renewal of ICM and ES cells. It functions independent of LIF/gp130/Stat3 pathway and prevents differentiation of ES cells to extraembryonic endoderm and trophectoderm lineages. Its expression has also been detected in embryonic carcinoma cells and germ line tumors indicating a therapeutic intervention |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.2% gelatin |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Mk, Gt |
| ProteinTarget: | Nanog |
| PackageSize: | 0.1 mg |
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