| CatalogCode: | NB100-56434 |
| ProductName: | NRIP Antibody |
| Product Description: | Rabbit Polyclonal anti-NRIP |
| Clonality: | Polyclonal |
| Immunogen: | A portion of amino acids 800-850 of human NRIP was used as the immunogen. |
| Specificity: | The amino acid sequence used is 100% homologous in human (isoforms a and b), mouse, rat and dog, 88% homologous in zebrafish and 82% homologous in xenopus. |
| CrossReactivity: | Dog, Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Peptide Affinity Purified |
| Uses: | WB: 1-3 ug/ml |
| Background: | Principal Names: Nuclear receptor Interacting Protein (NRIP); IQ motif and WD repeats 1 (IQWD1) Official Gene Symbol: IQWD1 Gene ID: 55827 (Human) Gene Map Locus: 1q24.2 (Human) WD-repeat proteins are a large family of eukaryotic proteins coordinating multi-protein complex assemblies and their role has been implicated in multiple cellular processes including signal transduction, transcriptional regulation, cell cycle control and apoptosis. NRIP is a novel 860a.a nuclear protein consisting of seven conserved WD40 domains and one NLS motif. It binds to androgen and glucocorticoid receptors and up regulates their transcriptional activity, thereby functioning as a nuclear receptor coactivator. Role of NRIP has been implicated in cell growth and also in cervical and prostrate cancer thus indicating a therapeutic intervention. Northern Blot analysis detected a high expression of NRIP in skeletal muscle and testis and low expression in heart, prostrate and adrenal gland. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Peptide Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Ca, Hu, Mu, Rt |
| ALTnames: | anti-Nuclear Receptor Interacting Protein antibody |
| ProteinTarget: | NRIP |
| PackageSize: | 0.1 mg |