| CatalogCode: | NB100-56409 |
| ProductName: | IL-20RA Antibody |
| Product Description: | Rabbit Polyclonal anti-IL-20RA |
| Clonality: | Polyclonal |
| Immunogen: | Amino acids 159-175 of human IL-20 receptor alpha protein were used as the immunogen. |
| Specificity: | The NCBI accession number for IL-20R alpha is NP_055247. The amino acid sequence used as immunogen is 100% homologous in human and chimp, and 82% homologous in mouse and rat. Both the expect ~70 kD band and an unknown ~90 kD band are seen in A375 cell lysate and are blocked by the immunizing peptide. The ~90 kD band alone is seen in A431 cell lysate, and it is also blocked by the immunizing peptide. This antibody was made against a portion of the extracellular domain of IL-20RA. Permeabilization of the cells during testing may affect antibody binding. |
| CrossReactivity: | Human, Mouse Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Affinity Purified |
| Uses: | WB: 1-3 ug/ml~; Flow: 2-5 ug/10; 6 cells~; |
| Control: | A375 |
| Background: | Principal Names: Interleukin 20 receptor alpha(IL20RA); IL-20R1; ZcytoR7; ZCYTOR7; Cytokine receptor Class II member 8(CRF2-8); Official Gene Symbol: IL20RA Gene ID: 53832 (Human) Gene Map Locus: 6q22.33-q23.1 (Human) IL20RA, is a subunit of IL20R, a member of Cytokine Class II receptor super family. It consists of a central transmembrane domain and functionally induces IL20 and IL26 signaling in epithelial cells and keratinocytes. It associates with IL-20RB and forms a functional receptor complex for IL20, IL19, and IL24. It also associates with IL-10RB and forms a unique heterodimeric functional receptor complex for IL-26. Upon ligand binding, it induces signaling through activation of STAT3 and STAT1. IL20RA is specifically expressed in skin suggesting a prominent role in growth and proliferation of keratinocytes. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | FACS, WB |
| SpeciesSummary: | Hu, Mu |
| ProteinTarget: | IL-20RA |
| PackageSize: | 0.1 mg |
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