| CatalogCode: | NB100-56355 |
| ProductName: | XAF-1 Antibody |
| Product Description: | Rabbit Polyclonal anti-XAF-1 |
| Clonality: | Polyclonal |
| Immunogen: | This antibody was developed against a mixture of KLH-conjugated synthetic peptides corresponding to aa 201-218 and 301-317 of human XAF1. |
| Specificity: | In human liver, a 34 kDa band should be observed. |
| CrossReactivity: | Human Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Affinity Purified |
| Uses: | WB: 1-2 ug/ml ~; IHC: 1:100 |
| Background: | The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | XAF-1 |
| PackageSize: | 0.1 mg |