| CatalogCode: | NB100-56344 |
| ProductName: | DAPK2 Antibody |
| Product Description: | Rabbit Polyclonal anti-DAPK2 |
| Clonality: | Polyclonal |
| Immunogen: | This antibody was developed against KLH-conjugated synthetic peptides corresponding to amino acids 325-342 and 347-364 of human DAPK2. It will cross-react with mouse and rat DAPK2. |
| CrossReactivity: | Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Affinity Purified |
| Uses: | WB: 2-4 ug/ml |
| Control: | rat kidney |
| Background: | Principal Names- DAPK2; Death-associated Protein Kinase 2; DRP-1; Death-kinase related protein 1 Official Gene symbol-DAPK2 Gene ID-23604 (human) Gene Map Locus- 15q22.31 DAPK2 is a 42 KDa calcium/calmodulin-dependant serine/threonine kinase localized in the cytoplasm. A member of DAP kinase family, DAPK2 has an N-terminal protein kinase domain, a conserved CAM binding domain and a 40A.A C-terminal tail required for homodimerization. Inactive DAPK2 is phosphorylated at conserved 'Ser-308', an inhibitory autophosphorylation site located within the CAM binding domain and is critical in inhibiting DAPK2 catalytic activation. Pro-apoptotic function of DAPK2 is activated by dephosphorylation, increase of intracellular Ca2+ levels, Ca2+ induced Calmodulin binding and homodimerization. Reports suggest DAPK2 along with DAPK1 induces membrane blebbing and formation of autophagic vesicles and plays a vital role in TGF-induced caspase-dependent Type-I and IFNã- induced caspase-independent autophagic type II cell death signaling. Northern Blot analysis detected abundant expression of DAPK2 mRNA in heart, lung and skeletal muscle |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | DAPK2 |
| PackageSize: | 0.1 mg |
order or
more information: | company product webpage |
| request information: |
|