| CatalogCode: | NB100-56334 |
| ProductName: | CCR1 Antibody |
| Product Description: | Rabbit Polyclonal anti-CCR1 |
| Clonality: | Polyclonal |
| Immunogen: | This antibody was raised against a synthetic peptide of human CCR1 protein. It will cross react with mouse CCR1. |
| Specificity: | In A375, a 42 kDa band should be observed. This antibody will cross react with mouse CCR1. |
| CrossReactivity: | Human, Mouse Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Rabbit antisera. |
| Control: | A375 |
| Background: | Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors (1). The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines (2-4). Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation (5,6). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-C-C Chemokine Receptor 1 antibody |
| ProteinTarget: | CCR1 |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Gao, J. L., P. M. Murphy. 1995. Cloning and differential tissue-specific expression of three mouse chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 receptor. J. Biol. Chem. 270:17494 2. Neote, K., D. DiGregorio, J. Y. Mak, R. Horuk, T. J. Schall. 1993. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72:415. 3. Murphy, P. M.. 1996. Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine Growth Factor Rev. 7:47. 4. Gao, J. L., A. I. Sen, M. Kitaura, O. Yoshie, M. E. Rothenberg, P. M. Murphy, A. D. Luster. 1996. Identification of a mouse eosinophil receptor for the CC chemokine eotaxin. Biochem. Biophys. Res. Commun. 223:679 5. Gao, J. L., T. A. Wynn, Y. Chang, E. J. Lee, H. E. Broxmeyer, S. Cooper, H. L. Tiffany, H. Westphal, J. Kwon-Chung, P. M. Murphy. 1997. Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J. Exp. Med. 185:1959. 6. Broxmeyer, H. E., S. Cooper, G. Hangoc, J. L. Gao, P. M. Murphy. 1999. Dominant myelopoietic effector functions mediated by chemokine receptor CCR1. J. Exp. Med. 189:1987 |
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