| CatalogCode: | NB100-56178 |
| ProductName: | TRAF5 Antibody |
| Product Description: | Rabbit Polyclonal anti-TRAF5 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide corresponding to amino acids 1-20 ([BLAST]MAHSEEQAAVPCAFIRQNSG[/BLAST]) of mouse TRAF5 was used as immunogen, GenBank no. AAH12702.1 |
| CrossReactivity: | Gerbil, Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | 0.05 ml Whole Rabbit antisera. |
| Uses: | WB, IHC(paraffin and frozen) and IP. |
| Control: | spleen, lymphoid, many cancer cell lines |
| Background: | The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. IMG-5765 recognizes TRAF5. Mouse TRAF5 is a 558 amino acid protein. |
| ProductRef: | 1. Zapata JM, M Krajewska, S Krajewski, S Kitada, K Welsh, A Monks, N McCloskey, J Gordon, TJ Kipps, RD Gascoyne, A Shabaik, and JC Reed. TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. 2000. J Immunol. 165:5084-5096. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | IHC-P, IHC-Fr, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | TRAF5 |
| PackageSize: | 0.05 ml |
| GeneralRef: | 1. Chung JY, YC Park, H Ye and H Wu. 2002. All TRAFs are not created equal:common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Science 115:679-688. |
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