| CatalogCode: | NB100-56170 |
| ProductName: | TRAF1 Antibody |
| Product Description: | Rabbit Polyclonal anti-TRAF1 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide corresponding to amino acids 1-22 (MASSSGSSPRPAPDENEFPFG) of human TRAF1 was used as immunogen, GenBank no. NP_005649.1. The peptide immunogen sequence is 90% conserved with cow and dog TRAF1. |
| CrossReactivity: | Human Not yet tested in other species. |
| Packaging: | 0.05 ml of Rabbit Whole antisera |
| Uses: | WB: 1:1000-1:2000~; IHC (paraffin): 1:1000-1:5000~; IHC (frozen): Users should optimize according to model and immunodetection system used (secondary reagents)~; IP: 1:50-1:200 |
| Control: | spleen, lymphoid, many cancer cell lines |
| Background: | The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. IMG-5727 recognizes TRAF1; human TRAF1 is a 416 amino acid protein. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | IHC, IP, WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | TRAF1 |
| PackageSize: | 0.05 ml |
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