| CatalogCode: | NB100-56061 |
| ProductName: | D4-GDI cleaved Antibody |
| Product Description: | Mouse Monoclonal anti-D4-GDI cleaved (97A1015), conjugated to PE |
| Clone: | 97A1015 |
| Clonality: | Monoclonal |
| Immunogen: | A synthetic peptide corresponding to the region of the Fas-induced cleavage site of human D4-GDI was used as the immunogen. |
| CrossReactivity: | Human, Mouse Not yet tested in other species. |
| Packaging: | 0.1 mg Mouse ascites. |
| Uses: | Flow: 0.5-1 ug/ 1x10; 6 cells |
| Control: | HL60 |
| Background: | D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms. |
| Storage: | Store at 4C. Do not freeze. |
| Isotype: | IgG2b, k |
| Host_Name: | Mouse |
| Buffer: | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-D4 GDI antibody |
| ProteinTarget: | D4-GDI cleaved |
| PackageSize: | 0.1 mg |
| Conjugate: | PE |