| CatalogCode: | NB100-56027 |
| ProductName: | FOXP3 Antibody |
| Product Description: | Mouse Monoclonal anti-FOXP3 (3G3), conjugated to FITC |
| Clone: | 3G3 |
| Clonality: | Monoclonal |
| Immunogen: | Full-length His-tagged murine FOXP3 was used as the immunogen. The precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. |
| Specificity: | Researchers are encouraged to titer the antibody for each application. |
| CrossReactivity: | Cross reacts with Human and Mouse. Not yet tested in other species. |
| Packaging: | 0.1 ml protein G purified Mouse ascites. |
| Uses: | Flow (Intracellular): researchers are encouraged to optimize according to model system used. |
| Control: | human PBMC |
| Background: | The fork head protein of Drosophila melanogaster, a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix'. The fork head domain binds B-DNA as a monomer but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein G purified |
| Isotype: | IgG1, k |
| Host_Name: | Mouse |
| Buffer: | 10mM NaCl, containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-Scurfin antibody |
| ProteinTarget: | FOXP3 |
| PackageSize: | 0.1 ml |
| Conjugate: | FITC |
| GeneralRef: | 1. Marc A. Gavin, Troy R. Torgerson, Evan Houston, Paul deRoos, William Y. Ho, Asbjørg Stray-Pedersen, Elizabeth L. Ocheltree, Philip D. Greenberg, Hans D. Ochs, and Alexander Y. Rudensky. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6659-64. Epub 2006 Apr 14. |
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