| CatalogCode: | NB100-56015 |
| ProductName: | Caspase-8 (CT) Antibody |
| Product Description: | Rabbit Polyclonal anti-Caspase-8 (CT) |
| Clonality: | Polyclonal |
| Immunogen: | Human Casp-8 (CT) (FLICE, MACH, Mch5) peptide. |
| CrossReactivity: | Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Peptide Affinity Purified |
| Uses: | WB: 0.5 ug/ml ~; IF/ICC: 2 ug/ml~; |
| Control: | Jurkat cell lysate can be used as positive control. |
| Background: | Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes pro-Caspase-8 autoactivation. FLIP, a catalytically inactive Caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Peptide Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | IF, ICC, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | Caspase-8 (CT) |
| PackageSize: | 0.1 mg |
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