| CatalogCode: | NB100-56010 |
| ProductName: | TSC2 Antibody |
| Product Description: | Rabbit Polyclonal anti-TSC2 |
| Clonality: | Polyclonal |
| Immunogen: | Human TSC2 / Tuberous sclerosis complex 2 / Tuberin (NT) peptide. |
| CrossReactivity: | Human, Mouse Not yet tested in other species. |
| Packaging: | 0.1 mg Rabbit antisera. |
| Uses: | WB: 1 ug/ml |
| Control: | L1210 cell lysate can be used as positive control. |
| Background: | Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. At least three isoforms of TSC2 exist. |
| Storage: | Store at 4C. Do not freeze. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ProteinTarget: | TSC2 (NT) |
| PackageSize: | 0.1 mg |
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