| CatalogCode: | NB100-56005 |
| ProductName: | TRAF3 Antibody |
| Product Description: | Rabbit Polyclonal anti-TRAF3 |
| Clonality: | Polyclonal |
| Immunogen: | Human TRAF3 / TNF receptor-associated factor 3 / CD40 binding protein / LMP1 associated protein 1 / CD40BP / LAP1 (CT) peptide. |
| CrossReactivity: | Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | 0.1 mg Rabbit antisera. |
| Uses: | WB: 1-2 ug/ml |
| Background: | Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1. Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-?B. Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-? receptor (LT?R) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LT?R. |
| Storage: | Store at 4C. Do not freeze. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | TRAF3 (CT) |
| PackageSize: | 0.1 mg |