| CatalogCode: | NB100-55993 |
| ProductName: | IRAK-2 (C2) Antibody |
| Product Description: | Rabbit Polyclonal anti-IRAK-2 (C2) |
| Clonality: | Polyclonal |
| Immunogen: | Murine mIRAK2 (C2) peptide. |
| CrossReactivity: | Mouse Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Peptide Affinity Purified |
| Uses: | WB: 0.5-1 ug/ml |
| Control: | Whole cell lysate from A-20 cells can be used as positive control. |
| Background: | The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-?B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-?B activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-?B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, murine IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion. IRAK2 is expressed in a variety of tissues. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Peptide Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Mu |
| ProteinTarget: | IRAK-2 (C2) |
| PackageSize: | 0.1 mg |
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