| CatalogCode: | | NB100-55939 |
| ProductName: | | Bad Antibody |
| Product Description: | | Rabbit Polyclonal anti-Bad |
| Clonality: | | Polyclonal |
| Immunogen: | | Human Bad (Bcl-2-like 8) peptide. |
| CrossReactivity: | | Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | | 0.1 mg Rabbit antisera. |
| Uses: | | WB: 0.5-1 ug/ml ~; IHC (paraffin): 2 ug/ml |
| Control: | | T24 cell lysates. |
| Background: | | Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax. Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival, whereas JNK-induced phosphorylation promotes the apoptotic role of Bad. |
| Storage: | | Store at 4C. Do not freeze. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | PBS containing 0.02% sodium azide. |
| ListPrice: | | 295 |
| AppSummary: | | IHC, WB |
| SpeciesSummary: | | Hu, Mu, Rt |
| ProteinTarget: | | BAD |
| PackageSize: | | 0.1 mg |
| more information: | | company product webpage |
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