| CatalogCode: | NB100-55895 |
| ProductName: | IRAK-M Antibody |
| Product Description: | Rabbit Polyclonal anti-IRAK-M |
| Clonality: | Polyclonal |
| Immunogen: | Human IRAK-M peptide. |
| CrossReactivity: | Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Peptide Affinity Purified |
| Uses: | WB: 0.5-1 ug/ml ~; IHC (paraffin): 2 ug/ml |
| Control: | Mouse spleen or rat kidney tissue lysate can be used as positive control. |
| Background: | Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-?B by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-?B activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Peptide Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | IRAK-M |
| PackageSize: | 0.1 mg |