| CatalogCode: | NB100-55882 |
| ProductName: | Caspase-12 (lrg) Antibody |
| Product Description: | Rabbit Polyclonal anti-Caspase-12 (lrg) |
| Clonality: | Polyclonal |
| Immunogen: | Murine Casp-12 (large) peptide. |
| CrossReactivity: | Human, Mouse, Rat Not yet tested in other species. |
| Packaging: | 0.1 mg of Rabbit Peptide Affinity Purified |
| Uses: | WB: 0.5-2 ug/ml ~; IHC (paraffin): 2 ug/ml |
| Background: | Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases Capase-8 and Caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and Caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including g-secretase presenilin and b-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Peptide Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | Caspase-12 (lrg) |
| PackageSize: | 0.1 mg |
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